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Illudin M
CAS No. 1146-04-9
Illudin M( —— )
Catalog No. M34856 CAS No. 1146-04-9
Illudin M is a cytotoxic sesquiterpene from the fungus O. illudens that alkylates DNA. It has a cytotoxicity of 6-100 nM against HL-60 human leukemia cells.Illudin M has anticancer activity and is a pre-drug for the synthesis of anticancer compounds.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 628 | Get Quote |
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| 5MG | 825 | Get Quote |
|
| 10MG | 1321 | Get Quote |
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| 25MG | 1822 | Get Quote |
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| 50MG | 2558 | Get Quote |
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| 100MG | 3384 | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameIlludin M
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NoteResearch use only, not for human use.
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Brief DescriptionIlludin M is a cytotoxic sesquiterpene from the fungus O. illudens that alkylates DNA. It has a cytotoxicity of 6-100 nM against HL-60 human leukemia cells.Illudin M has anticancer activity and is a pre-drug for the synthesis of anticancer compounds.
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DescriptionIlludin M is a cytotoxic fungal sesquiterpene that can be isolated from the culture medium of Omphalotus illudens mushrooms. Illudin M can alkylate DNA. Illudin M has anti-tumor activities.
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In VitroIlludin M (0.01-10 μM; 24-120 hours) shows cytotoxicity and induction of apoptosis in vitro.Apoptosis Analysis Cell Line:Panc-1 pancreatic carcinoma, HT-29 colon adenocarcinoma, non-malignant human foreskin fibroblasts (HFs) Concentration:0.01 μM, 1 μM, 10 μM Incubation Time:24 hours, 48 hours,72 hours, 96 hours, 120 hours Result:Showed a comparable induction of apoptosis in the tumour cells (86% in Panc-1; 48% in HT-29), but an even greater one in the HF (89%).
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorDNA Alkylator/Crosslinker | Apoptosis
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Research Area——
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Indication——
Chemical Information
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CAS Number1146-04-9
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Formula Weight248.32
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Molecular FormulaC15H20O3
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=C2[C@@H](O)C(C)(C)C=C2C(=O)[C@](C)(O)C11CC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Rainer Schobert, et al. Conjugates of the fungal cytotoxin illudin M with improved tumour specificity. Bioorg Med Chem. 2008 Sep 15;16(18):8592-7.?
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